With the slowly developing logistics system and the diversified logistics structure, there has been no efficient, reasonable and unimpeded logistics system in China. In the chemical raw material companies, there also exist the problems such as difficult coordination and inconsistent management within the supply chain. In view of the current development status and logistics industry issues, this paper, through the analysis for the impact of e-commerce on China’s logistics system, establishes the logistics optimization management of supply chain based on e-business. This optimizes the process operations for procurement, inventory, and distribution, then achieves integrated management and information integration sharing, and ensure that the companies respond to market demands in a timely manner and coordinate the production and transportation. Therefore, the use of integrated supply chain management is an essential step for chemical raw material companies to achieve logistics system informatization and rational management, and to establish the logistics distribution centre adaptive to the e-commerce environment in logistics optimization management.