Teixeira G., Brito A., Alves M., Finzer J., Malagoni R., 2013, Study of Supersaturation, Vibration Intensity and Time of Crystallization Variables in the Vibrated Bed Lactose Monohydrate Production Process, Chemical Engineering Transactions, 32, 2191-2196.
Lactose monohydrate crystallization was carried out in a batch vibrated-bed crystallizer. The crystallization trials were performed to determinate yield and mean crystal size prediction models and effect determination of variables supersaturation level, dimensionless vibration number and process time, using a central composite design. The parameters range adopted were in accordance with a previous study with same component, approximated of industrial processes, and fixed temperature of 50 °C. An optimization was made using response prediction models. It was observed a significant effect of process parameters discussed and the effectiveness of response prediction models, which explained maximum errors below 0.86 % in optimized condition.
