This paper evaluates the predictive performance of modern Computational Fluid Dynamics (CFD) methods in cyclone vortex-separation flows. Computer simulations are performed with the Eulerian-Eulerian (E-E) as well as Eulerian-Lagrangian (E-L) multiphase models, available is STAR-CCM+ CFD solver. Tested momentum closure strategies included typical two-equation isotropic turbulence models as well as high-order Reynolds Stress Models (RSM) and Large Eddy Simulation (LES) technique. The calculated results show satisfactory agreement compared to corresponding Laser Doppler Velocimetry (LDV) measurements and experimental values for the separation efficiency (?).