Flue Gas Desulphurization (FGD) is a key topic for most of combustion fossil fuel plants and industrial applications. Wet processes are usually preferred when the removal efficiency required to comply with environmental regulation exceed 90 %, but their flexibility makes them useful also for lower performance requirements. Recently, seawater has been considered as a viable absorbent for FGD processes in coastal and naval applications, when SO2 concentration is below 1000 ppmv. This liquid absorbs SO2 mostly thanks to its natural alkalinity (on average 2.4 mmol/L) and, of course, is also largely available. The main costs of seawater FGD (SW-FGD) plants are related to the pumps needed to supply the required amount of liquid and the cost of wash water restoration before discharge. Corrosion related to the presence of acidic seawater is also a major issue of these units. While thermodynamic limitations cannot be overcome, process design can be optimized to improve mass transfer rates and reduce seawater requirements while keeping a suitable absorber size. In this work, we report the experimental findings achieved by our group on process design and optimization of SW-FGD units. Two different kinds of SW-FGD units were tested and compared: a spray column and a packed column with structured packing.