The mathematical model of vapour condensation from the mixture with noncondensing gas in Plate Heat Exchanger (PHE) channels is presented. The model accounts for the change of process parameters along the heat transfer surface and local features of heat and mass transfer processes in PHEs channels with plates of different corrugations geometry. It consists of the system of ordinary differential equations with considerably nonlinear right parts. The software for its solution by finite difference method is developed. The validity of the model is confirmed by comparison with the experiment for steam-air mixture condensation in a PHE channel sample.