A perfect and effective management platform for hazardous chemicals will help improve the management capacity of companies and regulatory authorities in the field, thereby to reduce the potential safety hazards caused by chemicals. The purpose of this paper is to build a Web-based distributed management platform for hazardous chemicals, which adopts the B/S architecture integrated with the MVC operation mode. In the first half of phase, a waterfall development mode is accessed, and in the second half of phase, an iterative development mode is used to design and develop the program. After design of the platform, company will have a trial run for 5 months. The findings show that the chemical management platform based on the computer Web architecture can seamlessly integrate the existing business processes of the company. After the platform is accessed, it will help company improve the efficiency of business processes by about 20%, so that the multifaceted supervision and control will be enabled for the regulatory authorities and companies. This study provides the clues to the successful and efficient development for hazardous chemical management model in China. It indeed has important practical significance.