At present, the computer data acquisition system has been adopted in petrochemical industry. Based on the research theory of equipment data acquisition of petrochemical enterprises, and the Reactor multi-thread model, the computer data acquisition system of petrochemical equipment, which is composed of "FPGA", "ADC", "DDRII SDRAM" is designed. The Visual C++ software is used in Win7 system to simulate the petrochemical equipment system. The experimental results show that the newly designed computer data acquisition system for petrochemical equipment has good expansibility and system integration, and the system has a positive effect on improving the data collection of petrochemical equipment and enhancing the safety and stability of the whole petrochemical equipment operation. The monitoring range is enlarged and the speed of fault diagnosis and analysis is also improved. Therefore, the computer data acquisition system of petrochemical equipment based on Reactor multi-thread model can provide an operation template for more petrochemical equipment enterprises.