Vehicle transportation accounts for 80% of the dangerous chemicals transport volume in China, and it is of great significance to ensure safe transportation of dangerous chemicals. Based on the idea of "Internet +", this paper establishes a real-time monitoring system to realize all-round network management of vehicle information, driving status and security risks. This study designs a radio frequency identification (RFID) system to collect real-time data of dangerous chemicals transport vehicles, using a vehicle information concentrator to collect vehicle data and transmit it through mobile network; based on hardware design, it uses TOMCAT as the application server, Java as the system development language, and MYSQL as the database to develop a background management system for dangerous chemicals transport vehicles, and this system has a vehicle information management platform and a real-time vehicle monitoring platform. The application of the real-time monitoring system shows that the system can collect vehicle information, driver information, etc.; as well as locate the vehicles in real time and realize the danger warning of dangerous chemicals.