The destruction of materials exposed to atmospheric acid is an important part of the economic loss of acid deposition. In this paper, by analyzing the mechanism of material damage caused by acid deposition and referring to the damage function at home and abroad, the investigation method of outdoor material stock is put forward, and the economic loss of material damage is estimated by the analytical method estimation model, which provides a reference for estimating the latest economic loss of Atmospheric Acid deposition. The destruction of materials by acid deposition in the atmosphere is an important part of the economic loss of acid deposition. By estimating the acid rain area in South China, it is proved that the destruction of materials by acid deposition has a serious impact on the economy, and the damage of materials is calculated. The calculating method of material loss is briefly described. The economic loss of building materials is estimated by using material damage function and material life formula. The damage effect of acid deposition is quantified.