The polymerization process of acrylic fiber belongs to multi-input and multi-output nonlinear system. The polymerization continuous stirred reaction kettle temperature and polymerization conversion efficiency are important technological indexes in the polymerization production of acrylic fiber. The control level of the complex nonlinear process directly affects the differentiation rate of products. This study uses an intelligent self-adaptive control method to construct a mathematical model of acrylic fiber polymerization process, and the control method is designed in MATLAB. The corresponding simulation rules are made and the simulation of acrylic fiber polymerization process is completed.