The purpose of this study is to reduce the probability of fire in the chemical tank farm. To this end, fuzzy mathematics was adopted to establish the risk evaluation index system of the chemical tank farm. Besides, the grey relational analysis was introduced into the weight determination of analytic hierarchy process (AHP), and then applied to the safety evaluation of one actual chemical tank farm, to obtain the membership fuzzy set of risk factors in this storage farm. The results show that according to the principle of maximum membership degree, the risk influencing factors of chemical tank farm are graded as “slight”; while according to the scoring method, the safety status of chemical tank farm is evaluated as “good” using the scoring method, indicating that the conclusions of both are consistent, also meeting the actual situation. Therefore, the evaluation process reduces errors caused by human subjective factors, making the overall evaluation result more objective, scientific and reasonable, which is conducive to regional planning and resource allocation of major hazards, and reducing fire hazards within the region.