In order to explore the influence of meteorological conditions on the diffusion of atmospheric pollutants, this study takes Linfen City, a key national air pollution city, as an example, and uses the daily air pollution concentration data, wind direction and wind speed observation data and the ground weather observation data from 2016 to 2017 in this area to analyze the distribution characteristic and variation law of the main atmospheric pollutants (PM10, PM2.5, SO2, CO, O3, NO2). The influence of local meteorological conditions and general atmospheric circulation on the diffusion of atmospheric pollutants is discussed. The results show that the air pollution in Linfen City has obvious seasonal difference. The air quality is better in summer and autumn, and the main pollution is concentrated in heating period. The effect of meteorological factors on air quality index (AQI) is significantly different at different periods. In the non-heating period, there is a good negative correlation between precipitation and PM2.5, PM10, SO2 and NO2; the relative humidity, air temperature and cloud cover are negatively correlated with most pollution factors. In the heating period, the air temperature, relative humidity and cloud cover are positively correlated with most pollution factors. The wind speed is less correlated with AQI in the non-heating period, and only has a good negative correlation with NO2. In the heating period, the wind speed is negatively correlated with pollution factors except O3.