The mixing operation and design of agitated vessels for various chemical engineering applications may still represent a challenge due to the complexity of hydrodynamic fields established inside the reaction system. Computational Fluid Dynamics (CFD) is considered a valuable tool for the investigation of the complex turbulent flow field proper of mechanically agitated vessel (MAV). The use of CFD may effectively support the process engineer for the selection of the most proper impeller/vessel geometry and operative conditions to achieve homogeneous and fully turbulent conditions. In this work, experimental tests and CFD simulations were performed to study the Cr(VI) removal efficiency through nano-hematite particles (nHP) in MAV. More in detail, some solutions of Cr(VI) were treated using lab-made nHP, produced by a spinning disk reactor, in lab-scale agitated vessel and the kinetic of the removal process was experimentally studied varying the reactor/impeller configuration (impeller geometry) and the impeller rotational velocity. The obtained results were interpreted according to a CFD model of the system hydrodynamic field based on the k-? turbulent model whereas the kinetic data were fitted to a suitable mass transfer kinetic model.