The use of artificial intelligence (AI) techniques to address nonlinearity problems is gaining importance, mainly in context of industry 4.0. The present work was development of models based on artificial intelligence was performed to predict the concentration of cyclopentenol in a CSTR chemical reactor with the Van De Vusse kinetics. This reaction is known for its nonlinear behavior, which makes prediction difficult. Using simulations of this reactor in open and closed mesh combined with certain perturbations, a database was generated to train the models. The software MATLAB 2018a was used to implement the neural and the ANFIS systems. The input layer could be feed flow, feed temperature, heat provided by the thermal jacket, outlet temperature. The output were concentration of the component B and reactor temperature one step ahead. The models had good agreement, once presented remarkable performance reproducing the dynamics, obtaining R² values near to 1 and error index near to 0.