The efficiency of high-tech developmental zones in China is difficult to be evaluated since it is influenced by a variety of factors, and few works have been conducted for researching the comprehensive efficiency of high-tech zones in China. According to the Entropy Method, the comprehensive efficiency of high-tech developmental zones in China, which are established from 2007 to 2016, was estimated. The results indicated that the efficiency of patent output increased stably while the relationship between efficiency of technological investment and efficiency of revenue differed in three stages. In the first stage, the development of high-tech industries was driven by investment, however, in stage two, the main driving force was replaced by patents output of the last stage, while the rate of increase began to decrease in stage three, even with a higher patent output and technological investment. The reasons were illustrated and the suggestions were given.