Semibatch reactors (SBRs) are widely used to control the heat generation rate of exothermic reaction by tuning the dosing rate. To avoid the undesirable thermal runaway accidents, designing thermally safe operating conditions for SBRs is of high importance. In this work, a new simple computer aided method is developed to facilitate the process of designing safe conditions for liquid-liquid reactions that occur in the continuous phase following a slow reaction regime. The information required to design the safe operation parameters of dosing time (tD) and jacket coolant temperature (Tj) just include e, RH, ?tad,0 and MAT, which can be simply obtained from the reaction recipes or calorimetry tests. This method is developed on the basis of a deep insight into the thermal behaviors for isoperibolic SBRs. Two cases are conducted to verify the validity of the developed approach in this article.