Reduction of CO2 emissions is imperative to stop climate change. In the present study, the performance of a system based on chemical looping combustion in fixed bed is investigated. The plant allows power generation with obtainment of a CO2 rich stream ready for sequestration. To overcome the problems related to large temperature variations, use of two in series oxygen carriers, Cu/CuO and Ni/NiO supported on Al2O3, is investigated. CH4 was considered as fuel. A 1D numerical model was developed to estimate temperature and concentration profiles within the fixed bed as a function of time. A network of parallel reactors was designed to obtain continuous power generation at the turbine. A techno economic analysis was performed to estimate plant throughput, overall efficiency, total capital costs, and levelized cost of energy of the proposed system.