Industry 4.0 will have an impact on the employees in the workplace. Indeed, the increasing automation, the real time-oriented control system and more generally digital technologies may disrupt and interfere with the quality, competence, safety and equity of employees and operators. It is, therefore, necessary to prepare a new workforce for the factory of the future. It is thus possible either to carry out partial or total retraining of current employees - or to educate new employees hired from the younger and newer generations. The most likely solution would be a hybrid proposition of the two previous possibilities. The paper first describes the need for new skills, necessary for industry 4.0 ambitions. Then, as a consequence, a global vision and the new trends for Education 4.0 are presented. Next, a proposal for the synthesis of applications for the preparation of process safety 4.0 curricula is discussed.