The high accident rates, occupational diseases, and occupational illnesses have brought significant concerns in the different business activities, therefore over the years, rules have been generated to regulate and control the risks and diseases that employees may be subject to during work activities. Thus, the ILO (International Labor Organization) has provided provisions and regulations on OHS issues, and Colombia has adhered to them as a member state. In this respect, many companies around the country are committed to ensuring employees' health and providing safety to them during the development of their activities. A clear example of the above is a company whose activity is the commercialization of pharmaceutical and medicinal products, cosmetics, and toiletries, which has currently positioned itself as one of the leaders in this sector. This company has been in business for more than 20 years and has more than 960 points of sale throughout the country. Thus, after an extensive review of the company's guidelines and directives, it became evident that there are shortcomings in the lack of an OHSMS. Although some of the country's OHS regulations are applied, the need to apply a standard like ISO 45001 is highlighted. The application of ISO 45001 helps companies minimize significant risks that cannot be overlooked and improve quality standards, giving employers and employees more confidence. This work focuses on designing the management system for occupational safety and health of a company marketing pharmaceutical products in one of its offices located in Bogota. For this purpose, the requirements of the international standard ISO 45001:2018 are considered, and its implementation is intended to make employees feel at ease and safer when working. It should be noted that, for the company, the design of the Occupational Health and Safety Management System (OHSMS) will facilitate risk management and reduce the likelihood of occupational illnesses and accidents to which employees may be exposed. Additionally, it is expected that with the system's design, the company can be directed towards increasing the performance and continuous improvement of the organization, and it may involve having an advantage over companies that do not yet comply with this standard.