In the framework of design and installation of fire detection and fire alarm system in buildings, when high ceilings are involved, it is likely to run into the limits of the more common standards. Several regulations fix a ceiling height limit beyond which heat, smoke, and combustion gas detectors should not be mounted. Among the available technologies, the aspirating smoke detection (ASD) systems have the highest limit (i.e., 40 m according to BS 5839-1:2017). Nevertheless, this technology should not be used when processes that yield smoke, fumes, dust, etc., are present, and an alternative type of fire detector needs to be employed. This is due to the necessity to avoid false alarms, which is critical for successful fire detection and alarm systems. The concomitance of these two situations, i.e., dusty environments and high ceiling height, is not unusual in the industrial sectors. To investigate it, the state-of-the-art solution is adopting the principles of Fire Safety Engineering (FSE).