The properties of polymeric nanofibers make them versatile materials with multiple applications in the health area. Electrospinning (ES) and Solution Blow Spinning (SBS) are techniques commonly used in the manufacture of nanofibers because the experimental processes are simple, replicable, inexpensive, and carried out under environmental conditions. However, both techniques require the use of solvents whose retention may limit their use in biomedical applications. The objective of this work is to compare the morphological and mechanical characteristics of polycaprolactone nano/microfibers (PCL-F) obtained by these two techniques, as well as to evaluate the retention of the solvents used. Significant differences were found in the mechanical test, morphology, diameter and orientation of the PCL-F manufactured with both techniques. No significant differences were found the persistence of both solvents. PCL-F are commonly used in biomedical applications. These results indicate that when using nano/microfibers, the technique to be used should be carefully considered according to the desired application.