Carbon capture, utilization, and sequestration (CCUS) is an important option for meeting national carbon neutrality targets. However, the application of CCUS on an industrial scale and the extension of supply chain networks inevitably increase the exchange of information and material flows, creating a "media shifting" from environmental to safety risk issues. This work proposed system modeling and safety risk assessment for integrated regional CCUS systems. Considering CCUS modules, Aspen Plus simulation-based regional CCUS system is constructed. An integrated inherent safety index system is proposed to evaluate the risk characteristics. A CCUS system in Shandong Province is illustrated as a case study to analyze its safety risk. The results show that in terms of the overall inherent safety index, the emission source module has the highest risk, which is 2.67 times higher than that of the biological/geological utilization module.