With the rapid growth of population and urbanization, the amount of municipal solid waste (MSW) generated in China has increased significantly. However, existing MSW treatment methods are costly. To further reduce the treatment costs, a poly-generation system for MSW disposal integrating pyrolysis and incineration was proposed. The system provided the gasoline produced from pyrolysis as the auxiliary fuel for the incineration process. The poly-generation system with a feed rate of 50 t/h, a treatment capacity of 3.175 t/h for pyrolysis and 46.825 t/h for incineration, is simulated by Aspen platform based on our previous study. The sensitivity analysis shows that the feed rate of feedstocks, incineration temperature, and moisture content of MSW have a significant positive influence on power generation. The simulation results of the MSW poly-generation system provide a basis for the subsequent optimization analysis.