Metal-organic frameworks (MOF) are a new class of porous materials that have generated a lot of interest because of their crystalline structures, uniformly large surface area, open framework, and consistent yet adjustable cavities. They serve as photocatalysts and adsorbents for the removal of organic contaminants from wastewater. In this regard, MIL-100(Fe) as MOF is chosen and synthesized hydrothermally. So, this work is intended to prepare MOF-based photocatalysts and photocatalytic degradation of Pharmaceuticals like Sulfamethazine (SMT), present in wastewater using the prepared photocatalyst. The degradation studies will include the model development using Box-Behnken experimental design as RSM (response surface methodology), finding the optimum operating conditions of dosage, pH and initial concentration.