Leachate from landfill is one of the most relevant unsolved environmental issues, in particular related to the high ammonia content. In this work, the possibility of treating this waste stream with a combined approach that includes both physical and biological treatment was assessed. The process is composed by a first evaporation/condensation step in an innovative industrial technology (WastWa) developed by Solwa SrL, that allows separating an aqueous stream in which about half of the water volume and most of the ammonia are recovered, and a concentrated leachate stream. The ammonia-rich water stream can be then sent to a microalgal cultivation step for N removal, while the concentrated waste can either be partially used to provide micronutrients for microalgal growth or delivered to phytodepuration. The feasibility of the process was tested at lab scale by carrying out both batch and continuous experiments with Acutodesmus obliquus, a microalgal species isolated from a pond containing pretreated leachate from an urban landfill located in Lazio (Italy). This strain was cultivated both in untreated leachate and in the aqueous outlet stream of the WastWa unit. A simulation model of the microalgal growth process was implemented in Aspen Plus, keeping into account the chemical equilibrium and ionic speciation of the nutrients in solution as well as the pH. The model was able to reproduce well the experimental data, and can therefore be a useful tool to evaluate the feasibility of the proposed process at large-scale.