Because of the special nature of the chemical industry, there are many toxic and harmful gases hidden in chemical enterprises. The hidden safety hazards caused by the leakage cannot be overlooked so it is extremely urgent to effectively manage the leakage concentration of hazardous chemical products. Based on ZigBee wireless communication platform, this paper designs a detection platform of toxic gas leak according to the objective requirements and characteristics of toxic and hazardous gas detection in chemical enterprises. The platform collects the information of toxic and harmful gas leakage through the collection point and then uses the ZigBee network to transmit the data. Finally, the potential toxic gases in the environment of chemical enterprises can be effectively detected so as to achieve the optimization of the safety production level of chemical enterprises, prevent potential crises and achieve the purpose of protecting the staff safety and the enterprise property safety.