This research aims to propose mitigation measures to reduce the greenhouse gas emissions from passenger transport sector for Ho Chi Minh City, Vietnam. The Extended Snapshot tool is used to calculate the socio-economic development indicators and transport demand for base year 2013, and then estimate the transport demand based on the socio-economic development in target year 2030. In the base year 2013, the air pollutants (NO2, CO, PM10, Pb, etc.) are monitored at the six main stations to analyse the air pollution situation due to transportation activities. In the target year 2030, two scenarios are developed with the same socio-economic development and transport demand projections. Business-as-usual scenario does not consider the mitigation measures to reduce the greenhouse gas emissions while the countermeasure scenario does. Among the 940.5 kt CO2-eq reduction (15.0 % of emissions from passenger transport in 2030’s business-as-usual scenario), the promotion of energy-efficient vehicles helps to reduce 631.0 kt CO2-eq, followed by 146.7 kt CO2-eq reduction by modal shift from motorbike to mass rapid transports. The shift from fuel-motorbike to electric motorbike helps to reduce 83.2 kt CO2-eq, together with 41.4 kt CO2-eq reduction by shifting from conventional bus to compressed natural gas bus. The promotion of eco-driving with digital tachograph in passenger car helps to reduce 38.2 kt CO2-eq. As the co-benefit, the air pollution due to transportation activities might be reduced thanks to the implementation of mitigation measures to reduce the greenhouse gas emissions.