Ni Impregnated into Hypercrosslinked Polystyrene for N-Methyl-D-Glucosamine Synthesis
Mikhailov, Stepan
Doluda, Valentin Yu.
Sulman, Esther M.
Lakina, Natalia
Matveeva, Valentina G.
Sulman, Mikhail G.
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Mikhailov S., Doluda V.Y., Sulman E.M., Lakina N., Matveeva V.G., Sulman M.G., 2019, Ni Impregnated into Hypercrosslinked Polystyrene for N-Methyl-D-Glucosamine Synthesis, Chemical Engineering Transactions, 76, 865-870.
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D-glucose simultaneous catalytic hydro condensation with methylamine can be considered a promising way of N-methyl-D-glucosamine synthesis. In the current work, the use of novel polymeric nickel-based catalyst is proposed for the production of N-methyl-D-glucosamine in one step through reductive amination. The one-step N-Methyl-D-glucosamine synthesis was performed in a batch reactor using heterogeneous catalyst based on the polymeric matrix of hypercrosslinked polystyrene. The experiments on varying of temperature (80 – 140 °C), Ni loading (10 – 25 wt. %), D-glucose initial concentration (0.8 – 1.6 mol/L), and hydrogen pressure (40 – 60 bar) were performed in order to find optimal reaction conditions. The initial catalyst activity was found to be 1.3 kg(Glu)/(kg(Cat)*h). Catalysts activity after 10 cycles of D-glucose transformation showed a little slowdown and was calculated to be 1.1 kg(Glu)/(kg(Cat)*h) at 99.4 – 99.5 % D-glucose conversion.
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