In view of the disadvantages of various types of industrial close-boiling liquid mixtures and azeotropic as well as high energy consumption and easy pollution caused by traditional separation methods, the integrated distillation-membrane separation process has obvious economic advantages of energy saving and consumption reduction. The systematic and economic research is helpful to realize the win-win of environment and economy. In this paper, a comprehensive solution strategy for the integrated distillation-membrane separation process based on intelligent genetic programming (GP) is proposed. According to the characteristics of the material system and separation requirements, the most suitable membrane type and material can be matched, and then the most economical and environmentally friendly new distillation-membrane separation process can be calculated quickly. On this basis, the hot issues related to chemical industry are further discussed, including energy saving and consumption reduction, carbon or other pollutant discharge control, etc. At the same time, the improvement of the separation model and the cost model are predicted for different membrane types. The significant influence of the above key factors on the system and economy of the integration process is discussed. The modification measures of membrane materials are proposed to predict whether they have industrialization potential and finally promote the common development of membrane and integration technology effectively.