The use of fungicides based on plant extracts for the inhibition of phytopathogens has become a sustainable alternative for the environment. In this sense, research has developed biofungicides based on extracts of Allium cepa (A. cepa), Allium sativum (A. sativum), Zingiber officinale (Z. officinale) and Domestic Residual Oil (DRO) for the inhibition of Botrytis cinerea (B. cinerea) and Fusarium oxysporum (F. oxysporum). The inhibition of the two phytopathogenic fungi was evaluated in vitro, measuring the growth of mycelium of the fungi inoculated in the potato dextrose agar (PDA) culture medium, subjected to four treatments with three different doses (10, 15 and 20 %). The treatment that totally inhibited the mycelial growth of B. cinerea and F. oxysporum was the biofungicide composed by Z. officinale and domestic residual oil with a dose of 15 %. Finally, it is concluded that the use of the biofungicide is favorable for the control of fungi and could be used as an environmentally friendly alternative.