At Bayer process and plant safety has evolved over decades and remains a top priority. In 2020 the global Process and Plant Safety Department (PPS) jointly with Corporate Health & Safety (CHS) and divisional product supply representatives developed the PPS vision for the next four years. This task could not be achieved without understanding and addressing the major pain points of the divisional representatives with respect to process and plant safety. Therefore, an online survey and stakeholder interviews were organized resulting in a comprehensive status quo analysis. The results, which confirmed an overall high level of satisfaction with the performance of PPS, were analysed and provide a solid basis for five framework topics of the roadmap: safety performance, business driven innovation, risk-based approach, information sharing, and training. For each of these topics a cross functional and divisional team was formed to develop the concept of the “PPS Roadmap 2025”. Finally, these five teams aligned and prioritized topics and goals, resulting in the creation of eleven workstreams to drive the implementation of the roadmap. This paper describes the “PPS Roadmap 2025” and the collaborative process between corporate functions and operating Divisions that led to its creation.