Electrical energy storage is critical for a broader penetration of renewable energies with intermittent nature, such as solar and wind energy. The Acid/Base Flow Battery (AB-FB) is a unique, sustainable, and environmental-friendly storage technology with high electrolyte solution energy density. The method relies on reversible electrodialytic technologies using bipolar membranes to transform electrical energy into chemical energy related to pH gradients and vice versa. The charge phase is accomplished by using bipolar membrane electrodialysis, whereas the discharge phase is performed via bipolar membrane reverse electrodialysis. In a previous work, we developed an advanced multi-scale process model (Culcasi et al., 2021b), revealing the importance of operating conditions and design features for the AB-FB battery performance. For the first time, the current work attempts to optimize the AB-FB. The net Round Trip Efficiency and average net discharge power density were maximized in a two-objective optimization. The e-constraint method was used to construct curves of Pareto optimal solutions under various scenarios, thereby systematically assessing the effect of decision variables consisting of operating and design parameters. The gPROMS Model Builder® software package's optimization tool was used. This optimization study demonstrated that in a closed-loop configuration, optimized operating conditions and design features can be chosen to maximize net Round Trip Efficiency up to 64% and average net discharge power density up to 19.5 W m-2 using current commercial membranes.