The negative impacts of mining operations are generally intensified by the lack of preventive measures in the management of mining waste, one of them being the disposal of waste rock that generates drainage depending on its geology, mineralogical composition, geochemistry and solubility of the metals present. The objective of the research was to simulate the weathering of waste rock from mining activities in a wet column under controlled laboratory conditions. The physicochemical parameters were evaluated for 20 weeks. Results were obtained on leachate acidity as one of the main parameters, the pH was found to be between 6.0 and 7.5; this was due to the presence of carbonates as a neutralizer. The results allow taking measures to plan efficient waste management throughout the mining operation process, especially at mine closure, contributing to the control of negative impact.